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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Epigenetics of depression ： ウィキペディア英語版 Epigenetics of depression Depression is a serious behavioral disorder causing long lasting feelings of sadness and loss of interest. One form of depression is Major Depressive Disorder (MDD), in which symptoms of depression are present most days a week for 2 weeks or longer. Depression affects a large aspect of day-to-day activities such as thought process, sleep, and appetite. It can be accompanied by anxiety and decreased energy. According to the World Health Organization, depression affects about 350 million people worldwide and is the major cause of disability. Depression can be caused by the interaction of environmental and genetic factors. These factors include epigenetic modification of the genome in which there is a persistent change in gene expression without a change in the actual DNA sequence. ==Background on Epigenetics== Epigenetics refers to changes in gene regulation and expression that are long lasting but are not due to changes in the DNA sequence of the gene. These epigenetic changes can include a variety of alterations such as the addition or removal of methyl or acetyl groups to histones, methylation of DNA, and the action of non-coding RNAs. DNA Methylation refers to the adding of a methyl group to a cysteine nucleotide, which alters the genome and in mammals is thought to usually inhibit gene expression. Histone acetylation activates gene expression by the addition of an acetyl group. Histone methylation can work to either represses or activate gene expression. Epigenetic modifications represent an effect of the environment on the genome, and although they can be heritable, in some cases the effects can just be long lasting. One long lasting epigenetic alteration to the genome is caused by the exposure to stress and negative environments that can lead to epigenetic changes resulting in depression among other behavioral changes. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Epigenetics of depression」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.